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KMID : 0355219850090010065
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Journal of Korean Academy Oral Medicine
1985 Volume.9 No. 1 p.65 ~ p.76
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A Study on the Time Course Changes of Biogenic Amines in Response to Bite Injury
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Abstract
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The present studies, the investigations were undertaken for an attempt to analyze time course change of biogenic amines in response to bite injury in rats and guinea pigs, and obtained the following results that might be applicable to the forensic medicine and Forensic Odontology.
The histamine concentrations measured at rat abdominal skips were decreased during the first 8 hours and recovered to control levels after 12 hours. However the serotonin concentrations were decreased during the first hours and increased during 4-8 hours, and then returned to control levels thereafter. In contrast with these results, both histamine and serotonin concentrations were tended to increase in guinea pig skins, but the concentration of histamine showed maximum rate of increase immediately after injury and those of serotonin showed maximum rate of increase at 30 minutes.
The difference in the response of histamine and serotonine after injury between rats and ginea pigs revealed that there is species difference in the response of biogenic amines with regard to external stimuli.
These results suggest that the determination 3f biogenic amines in skin lesion of bite marks could be applied to the estimation of the elapsed time after antemortem injury.
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